Product Lineup and Specifications
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The major application area of CIM monolith
- Biological nanoparticles like virus, VLP, phage and exosome
- Peptides, proteins and their modifiers
- Antibodies (IgG and IgM)
- Nucleotides (from oligo to plasmid DNA)
- Bioproducts which contains above as impurities
Products line-up and specification
CIMmultus monolithic column
- A user-friendly and high-performance pre-packed column filled with high-speed “CIM Monolith” purification media in the advanced disposable polymer housing.
- Available in a wide range of functional group types that are familiar in biotechnology field such as anion/cation exchange and hydrophobic interaction.
- In combination with various size options, size from 1 mL to 8000 mL and excellent scale reproducibility of CIM, CIMmultus covers throughout the process from small laboratory preparation to full-scale bioproduction process.
CIMac analytical monolith
- A downsized column optimized for an HPLC analysis while keeping the characteristic high speed of CIM. Unprecedented low-pressure and high-speed analysis provides new values for PAT (process analytical technology) of biomacromolecules.
- Not only ion exchange and hydrophobic types that are widely used for bioanalysis, but also available in specifically designed types such as AAV full/empty separation or plasmid conformation analysis.
＜CIMac Lineup＞
| Ion exchange | Anion exchange: QA, DEAE, EDA |
|---|---|
| Cation exchange: SO3 | |
| Hydrophobic interaction | OH (weak), C4A (middle: low density butyl) , C4HLD (strong: high density butyl) |
| Reverse Phase | SDVB (mRNA / dsRNA analysis) |
| Multimodal | PrimaS (AEX + hydrogen bonding) |
| Special use | AAV full/empty (AAV analysis) |
| pDNA (plasmid conformation analysis) | |
| Oligo dT (mRNA analysis) | |
| r-Protein A, r-Protein G (IgG analysis) |
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